CAS 497-03-0: Tiglaldehyde

Stability Air sensitive, Light Sensitive Applications trans-Methyl-2-butenal is a reagent used in the synthesis of a cell adhesion inhibitors Peribysin E analog. Also used in the preparation of thiolactomycin-based KasA inhibitors in the treatment of tuberculosis. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Handore, Ki. et al.: Org. Lett., 15, 1894 (2013); Kapilashrami, K. et al.: J. Biol. Chem., 288, 6045 (2013);

Tiglic aldehyde was used in the concise total synthesis of 7-demethylpiericidin A11. It was used as starting reagent during the synthesis of alkyl-branched tetraene hydrocarbons, pheromone component for dried fruit beetle. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Methylbut-2-enal is an aldehyde that belongs to the class of fatty acid. It has been shown that 2-methylbut-2-enal inhibits the growth of bacteria by binding to the anhydrous sodium and tiglic acid in the bacterial cell wall. This binding prevents the formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. 2-Methylbut-2-enal also inhibits locomotor activity in mice, which may be due to its ability to inhibit acetylcholinesterase.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Trans-2-Methyl-2-Butenal