CAS 4972-11-6: 1-Hydroxy-2,2,6,6-tetramethyl-4-hydroxypiperidinium chloride

Applications 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants. References Flather, M., et al.: Lancet, 355, 1575 (2000); Sasso, F., et al.: Metabolism, 52, 675 (2003); Kass, D., et al.: Circ. Res., 94, 1533 (2004); Murdoch, C., et al.: Cardiovasc Res., 71, 208 (2006); Hahn, M., et al.: Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al.: Angew. Chem. Int. Ed., 51, 3699 (2012);