CAS 503070-57-3: 2-(2-(6-bromohexyloxy)ethoxymethyl)-1,3-dichlorobenzene

2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene

2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene is an organic compound that belongs to the family of carbamic acid derivatives. It has a primary amino group and a carbamic acid at the 2 and 3 positions, respectively. This molecule also has a formyl group on the 1 position. The amination reaction between this compound and formaldehyde will produce an imine as a final product. This reaction is catalyzed by heat or other oxidants like nitric acid or hydrogen peroxide. The formylation of this molecule is used in industrial preparations for the synthesis of chiral compounds with high selectivity for one enantiomer over another. The synthetic process can be carried out with high yield and the reaction selectivity is not affected by other factors such as pH or temperature changes.

Applications 2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene is an intermediate in the synthesis of Vilanterol Trifenatate-d4 (V260002). Vilanterol Trifenatate (V260000) is a long-acting β2 adrenergic receptor Agonist. It demonstrates prolonged bronchodilation in subjects with asthma and COPD. References Procopiou, P., et al.: J. Med. Chem., 53, 4522 (2010); Kempsford, R., et al.: Pulm. Pharmacol. Ther., 26,

Applications 2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene-d4 is the isotope labelled analog of 2-[2-(6-Bromohexyloxy)ethoxymethyl]-1,3-dichlorobenzene which is an intermediate in the synthesis of Vilanterol Trifenatate-d4 (V260002). Vilanterol Trifenatate (V260000) is a long-acting β2 adrenergic receptor Agonist. It demonstrates prolonged bronchodilation in subjects with asthma and COPD. References Procopiou, P., et al.: J. Med. Chem., 53, 4522 (2010); Kempsford, R., et al.: Pulm. Pharmacol. Ther., 26,