CAS 5048-82-8: ethyl 4-Aminocinnamate

Ethyl 4-aminocinnamate is a supramolecular, homologous, activated, linear polymer. It is used as an amine and phosphazene ligand in mesomorphic solid-state chemistry. It has a reversible covalent bond that can be thermally broken and re-formed. This property allows for the synthesis of polymers with functional groups on both ends of the molecule. The nitro group on this compound can be reduced to amine to give another functional group. Ethyl 4-aminocinnamate has been shown to have pharmacokinetic properties that are similar to those of ethyl 4-aminobenzoate (EB). EB is an inhibitor of NS5B polymerase that blocks RNA synthesis and leads to inhibition of viral replication. EB also inhibits ring opening reactions in the presence of nitro groups, which may explain its inhibitory effect on HIV RNA synthesis.