CAS 50824-05-0: 4-Trifluoromethoxybenzyl bromide

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4-(Trifluoromethoxy)benzyl bromide

4-(Trifluoromethoxy)benzyl bromide is a synthetic drug that has shown potential use in the treatment of tuberculosis. It has been shown to be an effective activator of PA-824, a drug that is currently being investigated for its anti-tuberculosis effects. 4-(Trifluoromethoxy)benzyl bromide also has apoptotic effects on Trichomonas vaginalis and intestinal parasites such as Entamoeba histolytica and Giardia lamblia. 4-(Trifluoromethoxy)benzyl bromide can activate chloride channels in liver cells, which causes hyperpolarization of the membrane potential and prevents calcium influx into the cell. The compound also binds to iron oxides in NMRI spectra and may have potential for use as a contrast agent for MRI imaging of tuberculosis lesions.

Applications 4-Trifluoromethoxybenzyl Bromide is a useful synthetic intermediate. It is used to prepare (nitro)[(trifluoromethoxy)benzyloxy]dihydroimidazo[2,1-b][1,3]oxazines with antitubercular activities. It is also used to synthesize tetrahydronaphthalenols with anti-allergic activities. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Li, X., et al.: Bioorg. Med. Chem. Lett., 18, 2256 (2008); Barlow, J., et al.: Eur. J. Med. Chem., 46, 1545 (2011)