CAS 50890-83-0: 1-methylindozole-3-carboxylic acid

Impurity Granisetron EP Impurity D Applications Granisetron Impurity D. References Bermudez, J., et al.: J. Med. Chem., 33, 1924 (1990),

1-Methyl-1H-indazole-3-carboxylic acid (1MICA) is a diazonium salt that is used in analytical chemistry as an indicator for the presence of chlorides. 1MICA can be synthesized by the methylation of indazole with formaldehyde and sodium cyanide. This compound is used as a preservative in pharmaceutical preparations, such as medicines and vaccines. 1MICA has been detected in synthetic cannabinoids, which are often used to treat chronic pain, although this use is not approved by the FDA. The chromatographic method for the detection of 1MICA consists of absorption on silica gel and elution with n-hexane:2-propanol:acetic acid (90:10:0.5).

1-Methylindazole-3-carboxylic acid is an excellent solvent with a proper boiling point.

1-Methylindazole-3-carboxylic acid is used as important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff. It is also used as a pharmaceutical adjuvant, Granisetron Impurity D. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1-Methyl-1H-indazole-3-carboxylic acid

1-Methylindazole-3-carboxylic acid

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi