The chemical substance known as (2R)-3-acetyl-1-(4-chloro-2-fluoro-phenyl)-2-cyclohexyl-4-hydroxy-2H-pyrrol-5-one, with the CAS number 512177-83-2, is a pyrrole derivative characterized by its complex molecular structure. It features a pyrrolone core, which is a five-membered heterocyclic compound containing both nitrogen and a carbonyl group. The presence of an acetyl group and a hydroxy group contributes to its reactivity and potential biological activity. The substitution of a cyclohexyl group and a halogenated phenyl moiety (with both chlorine and fluorine atoms) indicates that this compound may exhibit unique electronic and steric properties, which could influence its interactions in biological systems. Such compounds are often investigated for their potential pharmacological applications, including anti-inflammatory or anticancer activities. The specific stereochemistry denoted by (2R) suggests that the compound has a defined spatial arrangement, which is crucial for its biological function and interaction with target molecules. Overall, this compound represents a class of organic molecules with potential significance in medicinal chemistry.

(2R)-3-acetyl-1-(4-chloro-2-fluoro-phenyl)-2-cyclohexyl-4-hydroxy-2H-pyrrol-5-one

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CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).

CAS 512177-83-2: (2R)-3-acetyl-1-(4-chloro-2-fluoro-phenyl)-2-cyclohexyl-4-hydroxy-2H-pyrrol-5-one

CCR2-RA-[R]

Ref: TM-T14900

(R)-4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-3-hydroxy-1,5-dihydro-2H-pyrrol-2-one

Ref: IN-DA00DY59

CCR2 RA-[R]

Ref: 3D-FA101897

CCR2-RA-[R]

Ref: 54-BUP09886