CAS 5188-07-8: Sodium methanethiolate

Applications Sodium Methanethiolate-13C, is the labeled analogue of Sodium Methanethiolate (S644805), used as a nucleophile in organic synthesis. Sodium methanethiolate is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. References Bergman, A. & Wachtmeister, Chemosphere, 7, 949 (1978); Suzuki, T.,et al.: Bioorg. Med. Chem. Lett., 14, 3313 (2004)

Applications Strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers. E0 References Le Brazidec, J., et al.: J. Med. Chem., 47, 3865 (2004), Grem, J., et al.: J. Clin. Oncol., 23, 1885 (2005), Levason, W., et al.: Dalton Trans, 439 (2007),

Methanethiol is a compound that occurs naturally in the environment. It is used as a fungicide, insecticide and herbicide. Methanethiol inhibits the growth of microorganisms by binding to metal ions on the surface of cells. This prevents DNA replication and protein synthesis, leading to cell death. Methanethiol also has anti-inflammatory properties which may be due to its ability to inhibit adenosine A1 receptor activity in humans.

Sodium methanethiolate

Stability Readily Oxidized Applications A volatile aroma compound. We will provide a detailed procedure for the preparation of the thiol from the thiolacetate with spectral data upon request. References Majcher, M., et al.: J. Agric. Food Chem., 55, 5754 (2007), Akiyama, M., et al.: Food Sci. Technol. Res., 15, 233 (2009), Breme, K., et al.: J. Agric. Food Chem., 57, 8572 (2009),

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Sodium thiomethoxide solution

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Sodium methanethiolate is an antimicrobial agent that is a white, crystalline solid. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria. Sodium methanethiolate has been used for the treatment of infectious diseases, such as respiratory infections and skin infections, as well as autoimmune diseases and cardiovascular disorders. The oxidation catalyst in this compound may also have physiological effects on the body's cells and tissues.