CAS 52199-24-3: Pyridine, 2-[4-(bromomethyl)phenyl]-

2-(4-Bromomethylphenyl)Pyridine

2-[(4-Bromomethyl)phenyl]pyridine is a white crystalline solid that can be prepared by reacting 4-bromo-2-chlorobenzene with hexamethylenetetramine. 2-[(4-Bromomethyl)phenyl]pyridine has been used in the preparation of organic compounds, such as piperidine and 1,2,3,4-tetrahydroquinoline derivatives. This compound has been shown to exist as both a monomer and dimer. The molecule adopts an axial conformation with the phenyl group on one side of the plane. The crystal structure was solved for this compound using x-ray diffraction data.

Applications A phenylpyridine derivative used in the preparation of HIV protease inhibitors I and other pharmaceutical agents. References De Goey, D.A. et al.: J. Med. Chem., 52, 2571 (2009); Engstrom, K. et al.: J. Org. Chem., 71, 5369 (2006);