CAS 5222-73-1: 3,4-Dimethoxy-3-cyclobutene-1,2-dione

3,4-Dimethoxycyclobut-3-ene-1,2-dione

3,4-Dimethoxycyclobutane-1,2-dione is an amide with a carbonyl group. It is a synthetic compound that is reactive and chiral. 3,4-Dimethoxycyclobutane-1,2-dione has been used in the synthesis of glycopeptide antibiotics. The conjugates of this molecule have been envisaged as potential HIV treatments. 3,4-Dimethoxycyclobutane-1,2-dione has shown to have hydroxyl and hydroxy groups. This molecule belongs to the category of carbonyl compounds and amides.

Applications 3,4-Dimethoxy-3-cyclobutene-1,2-dione acts as a reagent for the synthesis and mechanism of action of squaramides with cytotoxic activity against human gastric carcinoma cells HGC-27. References Quintana, M., et al.: MedChemComm, 7, 550 (2016)

3,4-Dimethoxy-3-cyclobutene-1,2-dione (Dimethyl squarate) finds it uses in the synthesis of chiral squaramides, highly enantioselective catalyst for the Friedel-Crafts reactions of indoles, 3-(hydroxyamino)-4-methoxy-3-cyclobutene-1,2-dione, squarate derivatives of the O-SP-core antigens, methyl squarate derivative of the Ogawa O-SP-core antigen, o-quinodimethanes, benzocyclobutenes, quinones. It is employed as a starting material in the preparation of o-quinodimethanes, benzocyclobutenes, and quinones. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.