CAS 524-12-9: Wedelolactone
Formula:C16H10O7
InChI:InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI key:InChIKey=XQDCKJKKMFWXGB-UHFFFAOYSA-N
SMILES:O=C1C2=C(C=3C(O1)=CC(OC)=CC3O)OC=4C2=CC(O)=C(O)C4
Synonyms:- 1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one
- 1,8,9-Trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
- 1,8,9-trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one
- 6H-Benzofuro[3,2-c][1]benzopyran-6-one, 1,8,9-trihydroxy-3-methoxy-
- 7-Methoxy-5,11,12-Trihydroxycoumestan
- Wedelolactone
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Found 13 products.
Wedelolactone
CAS:Wedelolactone is a potent Î2-arrestin-biased G protein-coupled receptor-35 (GPR35) agonist, GPR35 has been shown to be a target of the asthma drugs cromolyn disodium and nedocromil sodium. Wedelolactone has anti-inflammatory, growth inhibitory, anti-cancer, anti-fibrotic, and pro-apoptotic effects. Wedelolactone stimulates ER genomic and non-genomic signalling pathways; it can significantly inhibit the activation of LX-2 cells, the underlying mechanisms of which included inducing Bcl-2 family involved apoptosis, up-regulating phosphorylated status of ERK and JNK expressions, and inhibiting NF-κB mediated activity.Formula:C16H10O7Purity:95%~99%Molecular weight:314.249Wedelolactone
CAS:M06041 - WedelolactoneFormula:C16H10O7Purity:>98%Color and Shape:SolidMolecular weight:314.2489929199219Ref: 10-M06041
1gTo inquire5mgTo inquire10mgTo inquire25mgTo inquire50mgTo inquire100mgTo inquire250mgTo inquireWedelolactone
CAS:Wedelolactone is a naturally occurring bioactive compound, classified as a coumestan, which is derived from the plant Eclipta alba, commonly referred to as false daisy. This polyphenolic compound exerts its effects through various modes of action, including inhibition of 5-lipoxygenase and modulation of NF-κB signaling pathways. The inhibition of these pathways suggests its potential role in the regulation of inflammation and cell proliferation. The primary uses and applications of Wedelolactone are explored in the context of its anti-inflammatory, hepatoprotective, and anticancer properties. Its ability to modulate molecular pathways linked to inflammation and cell cycle regulation positions it as a compound of significant interest in the development of therapeutic agents for diseases such as cancer, liver disorders, and inflammatory conditions. Research continues to explore its efficacy, molecular interactions, and potential applications in pharmacology, making it a focal point of study in natural product chemistry and medicinal sciences.Formula:C16H10O7Purity:Min. 98 Area-%Color and Shape:PowderMolecular weight:314.25 g/molWedelolactone
CAS:Formula:C16H10O7Purity:>98.0%(HPLC)Color and Shape:White to Dark green powder to crystalMolecular weight:314.25Wedelolactone
CAS:LactoneFormula:C16H10O7Purity:≥ 90.0 % (HPLC)Color and Shape:PowderMolecular weight:314.25Wedelolactone
CAS:Wedelolactone analytical standard provided with w/w absolute assay, to be used for quantitative titration.Formula:C16H10O7Purity:(HPLC) ≥99%Color and Shape:PowderMolecular weight:314.25Wedelolactone
CAS:Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.Formula:C16H10O7Purity:98.07% - 99.76%Color and Shape:SolidMolecular weight:314.25Ref: TM-T3384
1mg35.00€5mg74.00€10mg115.00€25mg185.00€50mg331.00€100mg437.00€500mg1,008.00€1mL*10mM (DMSO)52.00€
