CAS 52514-04-2: 2-[[(9Z)-1-Oxo-9-octadecen-1-yl]amino]ethanesulfonic acid

Applications N-Oleoyl Taurine which belongs to the class of N-Acyl Taurines were detected in beta cells of Langerhans islets causing insulin secretion results beta cell dysfunction in type 2 diabetes References Aichler, M., et al.: Cell Metab., 25, 1334-1347 (2017)

N-Oleoyl taurine, an amino-acyl endocannabinoid isolated from rat brain, along with several arachidonoyl amino acids such as N-arachidonoyl dopamine and N-arachidonoyl serine, have been derived from bovine brain. Mass spectral lipidomics analysis of rat brain revealed a series of fatty acyl amides of taurine, marking the discovery of a new class of compounds. These compounds, found in the kidney, are known to activate members of the transient receptor potential (TRP) family of calcium channels, with N-Oleoyl taurine specifically potentially activating TRPV1 and TRPV4 channels.

2-[[(Z)-Octadec-9-enoyl]amino]ethanesulfonic acid is a fatty acid that is metabolized by the liver. This compound has been shown to have insulin sensitizing and glucose regulating effects in mammalian cells. It also influences lipid metabolism, which may be due to its ability to regulate transcriptional activity of proteins such as amp-activated protein kinase and acetyl CoA carboxylase. 2-[(Z)-Octadec-9-enoyl]aminoethane sulfonic acid has been shown to improve metabolic profiles, including fatty acids and metabolites, in animals with heart disease and cancer. It may also be a useful biomarker for the diagnosis of metabolic disorders.