CAS: 52647-06-0

Betamethasone enol aldehyde Z isomer is a synthetic corticosteroid, which is derived from modifications of the naturally occurring glucocorticoid, cortisol. Its structure has been altered to enhance anti-inflammatory and immunosuppressive potency. As a Z isomer, it exhibits specific stereochemistry, potentially affecting its pharmacokinetics and interactions at the molecular level. The mode of action of this compound involves binding to glucocorticoid receptors, leading to the modulation of gene expression. This process results in the inhibition of pro-inflammatory cytokines and other mediators involved in immune responses. The distinct configuration of the Z isomer may enhance or modify certain binding affinities crucial for its efficacy. Betamethasone enol aldehyde Z isomer is primarily used in research settings focusing on understanding inflammatory pathways and designing therapeutic interventions for conditions like autoimmune disorders and chronic inflammation. Its applications also extend to studying receptor-ligand interactions and assessing the impact of stereochemistry in drug design.

Stability Hygroscopic Applications (Z)-Betamethasone-∆17,20 21-Aldehyde is the Z isomer and degradation production of Betamethasone (B327000) in acid medium;Also, it is derived from Betamethasone Dipropionate (B327005), which is a glucocorticoid. Used as anti-inflammatory and antibacterial ointment for dermatosis. References Hidaka, T., et al.: Yakugaku Zasshi, 100, 72-80 (1980); Dahlman-Ghozlan, K., et al.: Exp. Dermatol., 13, 65 (2004), Gounni Abdelilah, S., et al.: Clin. Immunol., 120, 220 (2006), Hertl, M., et al.: J. Clin. Invest., 116, 1159 (2006)