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CAS 53123-88-9: Rapamycin

Formula:C51H79NO13
InChI:InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key:InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N
SMILES:O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](O)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]
Synonyms:
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • 14S-Rapamycin
  • 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*S*1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-
  • 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • Antibiotic AY 22989
  • Ay 22989
  • See more synonyms
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Found 19 products.
  • Ref: IN-DA0035KC

    1g
    111.00€
    5g
    284.00€
    10g
    518.00€
    25g
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    10mg
    30.00€
    100mg
    39.00€
    250mg
    50.00€
    500mg
    75.00€
  • Rapamycin

    CAS:
    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.
    Formula:C51H79NO13
    Purity:Min. 95 Area-%
    Color and Shape:White Powder
    Molecular weight:914.17 g/mol

    Ref: 3D-AE27685

    1g
    728.00€
    2g
    988.00€
    5g
    1,863.00€
    250mg
    372.00€
    500mg
    530.00€
  • Rapamycin from Streptomyces hygroscopicus

    CAS:
    Rapamycin from Streptomyces hygroscopicus
    Formula:C51H79NO13
    Purity:By hplc: 99.14% (Typical Value in Batch COA)
    Color and Shape: white powder
    Molecular weight:914.17g/mol

    Ref: 54-BIR8101

    1g
    210.00€
    5g
    712.00€
    500mg
    128.00€
  • Sirolimus

    CAS:
    Formula:C51H79NO13

    Ref: TR-DRE-CA16970700

    10mg
    576.00€
  • Rapamycin (Sirolimus)

    CAS:
    Formula:C51H79NO13
    Color and Shape:White To Off-White Solid
    Molecular weight:914.19

    Ref: 4Z-R-182

    5mg
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  • Sirolimus

    CAS:
    Antibiotics nesoi
    Formula:C51H79NO13
    Color and Shape:Off-White White Powder
    Molecular weight:913.55514

    Ref: 45-1612765

    50mg
    471.00€
  • Rapamycin-13C,d3 (contains d0) Technical Grade

    Controlled Product
    CAS:
    Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0. References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),
    Formula:C50CH76D3NO13
    Color and Shape:Neat
    Molecular weight:918.18

    Ref: TR-R124003

    1mg
    689.00€
    5mg
    2,733.00€
    10mg
    5,029.00€
  • Rapamycin, 98+%

    CAS:
    Blocks cytokine-mediated signal transduction pathwaysRapamycin is used to inhibit tumor growth by halting tumor cell proliferation and suppressing tumor angiogenesis. It forms a complex with FKBP12 that binds and inhibits the molecular target of rapamycin (mTOR) as well as suppresses the immune system, preventing transplant rejection. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
    Formula:C51H79NO13
    Purity:98+%
    Color and Shape:White to cream to yellow, Powder or crystals or crystalline powder
    Molecular weight:914.19

    Ref: 02-J62473

    50mg
    179.00€
    100mg
    231.00€
    200mg
    288.00€
  • Rapamycin-13C,d3 (contains d0) - Technical Grade

    Controlled Product
    CAS:
    Binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. Induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.
    Formula:C50CH76D3NO13
    Purity:Min. 95%
    Molecular weight:918.18 g/mol

    Ref: 3D-BR177694

    1mg
    1,073.00€
    2mg
    1,694.00€
    5mg
    3,655.00€
  • Rapamycin

    CAS:
    Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.
    Formula:C51H79NO13
    Purity:97.08% - 99.03%
    Color and Shape:Yellow Solid
    Molecular weight:914.17

    Ref: TM-T1537

    1g
    283.00€
    10mg
    35.00€
    25mg
    48.00€
    50mg
    52.00€
    100mg
    69.00€
    200mg
    106.00€
    500mg
    188.00€
    1mL*10mM (DMSO)
    50.00€
  • Rapamycin

    CAS:
    Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's. References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),
    Formula:C51H79NO13
    Purity:>85%
    Color and Shape:Neat
    Molecular weight:914.17

    Ref: TR-R124000

    5mg
    130.00€
    50mg
    512.00€
    100mg
    876.00€
  • Sirolimus

    CAS:
    Color and Shape:Neat

    Ref: 04-CA16970700

    10mg
    605.00€
  • Rapamycin

    CAS:
    M02444 - Rapamycin
    Formula:C51H79NO13
    Purity:98%
    Color and Shape:Solid, Crystalline Powder or Granules or Powder
    Molecular weight:914.187

    Ref: 10-M02444

    1g
    102.00€
    5g
    408.00€
    10mg
    24.00€
    50mg
    31.00€
    100mg
    34.00€
    250mg
    96.00€
    500mg
    91.00€
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:>98.0%(HPLC)
    Color and Shape:White to Almost white powder to crystal
    Molecular weight:914.19

    Ref: 3B-R0097

    25mg
    83.00€
  • Rapamycin - Bio-X ™

    CAS:
    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells. Rapamycin - Bio-X ™ is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.
    Formula:C51H79NO13
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:914.17 g/mol

    Ref: 3D-BR164324

    10mg
    140.00€
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:98.0 - 102.0 % (anhydrous basis)
    Color and Shape:White to yellow crystalline powder
    Molecular weight:914.17

    Ref: 7W-GA7417

    5mg
    33.00€
    25mg
    79.00€
    50mg
    148.00€
    100mg
    243.00€
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:95%~99%
    Molecular weight:914.187

    Ref: BP-BP1196

    ne
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  • Rapamycin

    CAS:
    Rapamycin
    Purity:≥98%
    Molecular weight:914.17g/mol

    Ref: 54-BUP17166

    10mg
    53.00€
    25mg
    64.00€
    50mg
    76.00€
    100mg
    96.00€
    200mg
    163.00€
    500mg
    273.00€
  • Everolimus EP Impurity A

    CAS:
    Formula:C51H79NO13
    Molecular weight:914.2

    Ref: ST-EA-CP-E33001

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