CAS: 53173-70-9

Roflumilast is a thionyl chloride (ClSO2) derivative that has been used in the preparation of the drug. The condensation reaction of 3-Difluoromethoxy-4-hydroxybenzaldehyde with sulfamic acid produces roflumilast. The efficiency of this reaction depends on temperature and solvent. Roflumilast has been shown to be effective against some types of cancers, such as non-small cell lung cancer, and inflammatory diseases, such as asthma. In addition to its chemical structure, roflumilast is an intermediate in the synthesis of other medicines that are used to treat pulmonary disorders and inflammation.

3-(Difluoromethoxy)-4-hydroxybenzaldehyde