CAS 53772-82-0: cis-Flupenthixol

The model system is a useful tool for the study of dopamine receptors. It has been shown to be an effective inhibitor of 5-HT2 receptors and locomotor activity in vitro. The model system has also been used to demonstrate that low doses of flupenthixol and flupentixol act as p-gp substrates in vitro, which may be due to their ability to inhibit dopamine uptake. This model system has also been used to develop an analytical method for measuring dopamine levels in human serum. Designed by:

cis-(Z)-Flupentixol dihydrochloride is an antipsychotic medication, which is a derivative of thioxanthene. Synthesized in laboratories, its structure is characterized by the presence of a cis-(Z) configuration, which influences its binding properties to dopamine receptors. The primary mode of action of cis-(Z)-Flupentixol dihydrochloride involves antagonism at dopamine D1 and D2 receptors, thereby modulating neurotransmitter activity in the brain. This action is critical in the attenuation of symptoms associated with psychotic disorders, through the rebalancing of dopaminergic pathways. In clinical settings, cis-(Z)-Flupentixol dihydrochloride is used to manage and treat schizophrenia and other psychiatric conditions marked by symptoms such as hallucinations, delusions, and emotional withdrawal. It is also sometimes employed in the treatment of moderate depression. The compound's efficacy in altering synaptic communication highlights its importance in neuropharmacology, offering insights into the therapeutic manipulation of neurotransmitter systems. Understanding its receptor interactions continues to enhance our comprehension of psychiatric disorder management and the development of targeted therapies.

Cis-flupentixol