4β-Hydroxywithanolide E is a naturally occurring steroidal lactone belonging to the withanolide class, which are derived from the plant genus Withania, particularly Withania somnifera, commonly known as ashwagandha. This compound is characterized by its unique steroidal structure, which includes a hydroxyl group at the 4β position. It exhibits a range of biological activities, including anti-inflammatory, antioxidant, and potential anticancer properties, making it of interest in pharmacological research. The compound's mechanism of action is thought to involve modulation of various signaling pathways, contributing to its therapeutic effects. Additionally, 4β-Hydroxywithanolide E is studied for its role in enhancing cognitive function and reducing stress, aligning with the traditional uses of ashwagandha in Ayurvedic medicine. Its solubility and stability can vary depending on the formulation, which is important for its application in herbal supplements and potential drug development. Overall, 4β-Hydroxywithanolide E represents a significant area of interest in natural product chemistry and medicinal research.

4β-Hydroxywithanolide E

54334-04-2: NSC 212509, 4β-Hydroxywithanolide E, Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)-

5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ẟ-lactone

4bHWE inhibits colon cancer growth, alters splicing, is anti-inflammatory, aids in diabetes/obesity, and may be chemopreventive.

4-Hydroxywithanolide E is a natural compound that has been shown to inhibit the growth of breast cancer cells, including MDA-MB-231 cells. It is an antioxidant and may reduce oxidative damage to DNA and proteins by reacting with reactive oxygen species. 4-Hydroxywithanolide E also increases the expression of survivin, which is important for cell cycle arrest and DNA repair. This compound has been shown to induce cell death in vitro through a variety of mechanisms, including reactive oxygen species generation, induction of apoptosis, or inhibition of protein synthesis. 4-Hydroxywithanolide E has also been shown to decrease the size of fat cells in vivo.

CAS 54334-04-2: 4β-Hydroxywithanolide E

5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ẟ-lactone

Ref: IN-DA01LIYS

4β-Hydroxywithanolide E

Ref: TM-TN3070

4-Hydroxywithanolide E

Ref: 3D-ECA33404