CAS 5451-09-2: Aminolevulinic acid hydrochloride

Methylaminolevulinate impurity B CRS

5-Aminolevulinic acid hydrochloride is the HCl salt of 5-Aminolevulinic acid (5-ALA). 5-ALA is used in photodynamic therapy due to its properties as a photosensitizer, with applications in treatment of acne. 5-Aminolevulinic acid hydrochloride is used for visualisation of tumorous tissue in neurosurgical procedures enabling a reduction in the tumour residual volume and prolongation of progression-free survival in people with malignant gliomas. 5-ALA also has potential applications in diagnostic oncology in detection of bladder cancer. As part of our GMP product offering, we can provide GMP 5-ALA as an API. Contact us to discuss your needs.

Non-aromatic amino-compounds with oxygen function

Particle size < 0.25 mm

5-Aminolevulinic acid hydrochloride finds an important role as a precursor in the synthesis of tetrapyrroles such as chlorophyll and heme. It is widely utilized in photodynamic therapy of diseases namely, Paget’s disease and human papillomavirus (HPV) infection-associated cervical condylomata acuminata. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.

5-Aminolevulinic acid hydrochloride is a diagnostic agent that can be used to diagnose bladder cancer. It is also used in DNA sequencing experiments and in the study of mitochondrial functions and energy metabolism. 5-Aminolevulinic acid hydrochloride is an intermediate in the heme biosynthetic pathway, which is synthesized from glycine and succinyl-CoA by the enzyme aminolevulinic acid synthase. Structural analysis of this product has revealed that it has a molecular weight of 256.2 g/mol, with a particle size less than 0.25 mm. As part of our GMP product offering, we can provide GMP 5-ALA as an API. Contact us to discuss your needs.

5-Aminolevulinic acid hydrochloride (5-ALA) serves as an intermediate in the body's heme biosynthesis and is the universal precursor of tetrapyrroles.

Photodynamic Therapy of Actinic Keratosis. Porphobilinogen synthase substrate that produces endogenous porphyrins useful for sensitizing cells in photodynamic therapy. Intermediate in heme and chlorophyll biosynthesis. Estimation of 5-aminolevulinic acid dehydratase. PBG formed in the assay is determined spectrophotometrically with Ehrlich's reagent. Used in Porphyrin test for differentiation of Haemophilus species. Enzymes that convert ALA to porphyrins in the biosynthesis of hemin (X factor) are not produced by H. influenzae, H.aegyptius and H. canis. These enzymes are produced by H. parainfluenzae, H. parahaemolyticus, H. gallinarum, H. parasuis, H. parahaemolyticus and H. aphrophilus. A positive reaction is indicated by an orange-red fluorescence.

5-Amino-4-oxopentanoic acid hydrochloride

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.