CAS 5453-67-8: Dimethyl 2,6-pyridinedicarboxylate

Applications Dimethyl 2,6-Pyridinedicarboxylate (cas# 5453-67-8) is a compound useful in organic synthesis.

2,6-Pyridinedicarboxylic acid dimethyl ester is a drug that has shown anticancer activity in animal models. It binds to DNA, forming a ternary complex with the DNA and the enzyme topoisomerase I. The binding of this drug to the enzyme prevents it from breaking the DNA strands during replication, causing the cell to die. It has been shown that 2,6-pyridinedicarboxylic acid dimethyl ester can be used as a non-competitive inhibitor of topoisomerase I. Furthermore, it has been demonstrated that 2,6-pyridinedicarboxylic acid dimethyl ester is able to bind to human endometrial cancer cells with high affinity. Finally, 2,6-pyridinedicarboxylic acid dimethyl ester was found in x-ray crystal structures of complexes with hydrogen bonds and low activation enthalpy and entropy.

Eight macrocyclic bisamides and tetramides have been synthesized by reaction of dimethyl pyridine-2,6-dicarboxylate 1 with α,ω-diaminoethers in methanol as a solvent. Silver(I) coordination polymer and nine-coordinated cadmium(II) complex with dimethyl pyridine-2,6-dicarboxylate supported by solid state and electrochemical studies This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Dimethyl pyridine-2,6-dicarboxylate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.