CAS 546-67-8: Lead(IV) acetate

Stability Hygroscopic, Moisture Sensitive Applications Lead(IV) acetate is most commonly used in synthetic chemistry as an oxidizing agent, and is a versatile precursor for lead-containing compounds. Lead(IV) acetate is a toxic substance to humans, and is also known to induce oxidative damage and hyperlipidemia in rats. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Newairy, A., et al.: Food Chem. Toxicol., 47, 813 (2009); Rahman, S. & Sultana, S.: Chem.-Biol. Int., 160, 61 (2006); Yadav, R.: Synlett, 2012, 1262 (2012)

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Lead(IV) acetate, 95%

Plumbic acetate releases acetate ions, acts as an oxidizer for sulfur (VI) synthesis, and reacts with thiodithiazyl dichloride.

Lead acetate is an alkanoic acid that can be used as a lead salt. It has been shown to react with protocatechuic acid in the presence of hydrogen to form lead(IV) protocatechuate and acetic acid. This reaction mechanism can be applied to the analysis of other organic acids, such as fatty acids. Lead acetate also inhibits protease activity in vitro and has been shown to have therapeutic effects against autoimmune diseases and polycystic ovarian syndrome. Lead acetate has a low toxicity and is stable when mixed with trifluoroacetic acid or nitro compounds, but very reactive with strong oxidizing agents such as hydrochloric acid or hydrogen fluoride. Lead acetate is non-hygroscopic and insoluble in water, making it suitable for use in analytical chemistry.

Lead(IV) tetraacetate,

Lead(IV) acetate is an important oxidizing agent and a source of acetyloxy group used in organic synthesis. For example, 1,4-dioxene is prepared from dioxane involving 2-acetoxy-1,4-dioxane as an intermediate. Similarly, it is used for the preparation of bis(trifluoromethyl)diazomethane from hexafluoroacetone hydrazone. It also reacts with alkenes, alcohols having a delta-proton and di-n-butyl d-tartrate to get gamma-lactones, cyclic ethers and n-butyl glyoxylate respectively. It induces the cleavage of 1,2-diols to the corresponding aldehydes or ketones. It is actively involved in the Kochi reaction for the decarboxylation of carboxylic acids to alkyl halides and used as an alternative reagent to bromine in the Hofmann rearrangement. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.