CAS 552-94-3: Salicylsalicylic acid

Impurity Acetylsalicylic Acid EP Impurity E (Aspirin EP Impurity E) Applications Nonacetylated aspirin analog. Analgesic, anti-inflammatory. Acetylsalicylic Acid Impurity E (Aspirin Impurity E) Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980), Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),

Salsalate is a non-steroidal anti-inflammatory drug that is used to treat chronic arthritis and other diseases. It is a prodrug of salicylic acid, which inhibits the production of prostaglandin E2 and thromboxane A2. Salsalate has been shown to induce weight loss in obese mice, improve insulin sensitivity, and reduce hepatic steatosis in experimental models. This drug also inhibits the progression of chronic arthritis by reducing inflammation. Salsalate may be beneficial for people with HIV infection because it reduces viral load levels and improves CD4+ T cell counts. The mechanism of action for this drug is not fully understood but may involve hydrogen bonding interactions with proteins.

Salsalate is a nonsteroidal anti-inflammatory drug that belongs to the class of drugs known as salicylates. It is used to treat chronic arthritis and osteoarthritis. Salsalate inhibits the production of inflammatory mediators such as prostaglandins and cytokines, thereby reducing inflammation and pain. The mechanism of action has been shown in experimental models, which indicates that salsalate may inhibit transcriptional regulation, protein synthesis, or DNA replication. Salsalate also inhibits the production of cholesterol by binding to fatty acids in adipose tissue. This drug has been shown to reduce hepatic steatosis and prevent liver damage caused by nonsteroidal anti-inflammatory drugs (NSAIDs). Salsalate binds with high affinity to hydrogen bonding interactions with dimethyl fumarate, a drug used for treatment of multiple sclerosis (MS).

Salsalate

Salicylsalicylic acid is used in organic synthesis and functions as a plant hormone, as a key ingredient in topical anti-acne products. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Salsalate

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Isotope labelled Nonacetylated aspirin analog. Analgesic, anti-inflammatory. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980), Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),

Aspirin impurity standard

Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic

Esters of salicylic acid and its salts not elsewhere specified or included