CAS 55368-40-6: Benzenecarboximidamide,4,4'-(2,5-furandiyl)bis-, dihydrochloride (9CI)

Furamidine: selective PRMT1 inhibitor, binds AT DNA sequences, inhibits leukemia cell proliferation.

Applications Furamidine is a diphenylfuran compound belonging to an important class of antimicrobial and antiparasitic agents. Furamidine and its analogues also display antitumor activities and showed antiproliferative activities against various tumor cell lines. References Lansiaux, A. et al.: Cancer Res., 62, 7219 (2002); Steck E.A. et al.: Exp. Parasitol., 52, 404 (1981); Balzarini, J. et al.: Incest. New Drugs, 1, 103 (1983);

Furamidine is a molecule that has the properties of a maleate and is used in the treatment of biliary tract disorders. Furamidine dihydrochloride (FD) is a prodrug that is converted to furamidine by hydrolysis in vivo, which binds to DNA and blocks DNA replication. FD has been shown to inhibit the growth of K562 cells and human muscle cells, but not other cells such as hepatocytes. The mechanism may be related to its ability to interfere with methyltransferase activity, which leads to decreased production of proteins from dna templates. Furamidine has also been shown to have antioxidant properties and can protect against DNA damage caused by hydrogen chloride or nitric oxide.