Hexamethonium hydroxide, with the CAS number 556-81-0, is a quaternary ammonium compound primarily known for its role as a ganglionic blocker. It is characterized by its ability to inhibit the transmission of nerve impulses in the autonomic nervous system, particularly affecting the sympathetic and parasympathetic pathways. This compound is typically a white crystalline solid that is soluble in water due to its ionic nature. Hexamethonium hydroxide has been utilized in pharmacological research and has historical significance in the treatment of hypertension, although its clinical use has diminished with the development of newer antihypertensive agents. The compound's mechanism of action involves competitive antagonism at nicotinic acetylcholine receptors located in autonomic ganglia. Safety and handling precautions are essential, as with many chemical substances, due to potential toxicity and side effects associated with its pharmacological activity. Overall, hexamethonium hydroxide serves as an important reference compound in studies of autonomic pharmacology and neuromuscular transmission.

Hexamethonium hydroxide

556-81-0: Diquat-6(OH)2, 1,6-Hexanediaminium, N,N,N,N′,N′,N′-hexamethyl-, dihydroxide, 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, hydroxide (1:2), Ammonium, hexamethylenebis[trimethyl-, dihydroxide, Hexamethylenebis[trimethylammonium hydroxide],  N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dihydroxide,  Hexane-1,6-bis(trimethylammonium), Hexamethonium hydroxide

CAS 556-81-0: Hexamethonium hydroxide

Hexamethonium Dihydroxide (ca. 25% in Water)

Ref: 3B-H1762

Hexamethonium hydroxide solution

Ref: IN-DA003QWL

Hexamethonium dihydroxide (ca. 25% in water)

Ref: 54-OR72868