CAS 55661-08-0: 4-Methoxy-2,6-dimethylbenzenesulfonyl chloride

2,6-Dimethyl-4-methoxybenzenesulphonyl chloride

4-Methoxy-2,6-dimethylbenzenesulfonylchloride (4MDBS) is a nucleophilic reagent that reacts with the electron withdrawing group of a molecule to form an electrophilic sulfonium ion. This reaction occurs between 4MDBS and the chloride ion in the following mechanism: The product of this reaction is called a sulfonium salt. The addition of methanol results in a mechanistic reaction, which is shown below: This reaction leads to the formation of a chloromethyl ether and an alcohol. When 4MDBS reacts with acetone, it forms an ester and an alcohol: This reagent has been used as a selective agent for the determination of the concentration of chloride ions in solution. It also has been used to characterize molecules by measuring their spectrum and profile. The reactions between 4MDBS and various molecules have been extensively studied.