CAS 5624-26-0: 5-Hydantoinpropionic acid

3-(2,5-Dioxoimidazolidin-4-yl)propanoic acid (3DAP) is a histidine analog that belongs to the group of fatty acid derivatives. It has been shown to be effective in the diagnosis of obesity and provides a new approach for the treatment of obesity. 3DAP binds to organic anion transporters, which are proteins that transport organic anions across cell membranes. This binding inhibits the transport of organic anion substrates and leads to increased concentrations of these substrates in blood plasma. 3DAP is a competitive inhibitor against estrone sulfate, which is one of its major metabolites. 3DAP has shown efficacy in animal models for obesity, diabetes, and hepatic steatosis.

Impurity Carglumic Acid Impurity B Applications 3-(2,5-Dioxoimidazolidin-4-yl)propanoic Acid is defined as combinational markers to distinguish hepatocellular carcinoma (HCC) from cirrhosis (CIR). References Shao, Y., et al.: J. Proteome Res., 14, 906-916 (2015)