5-A-pregnane-3β-21-diol-20-one, also known as 21-hydroxyprogesterone, is a steroid hormone that plays a crucial role in the biosynthesis of other steroid hormones. It is characterized by its structure, which includes a pregnane backbone with hydroxyl groups at the 3β and 21 positions and a ketone at the 20 position. This compound is primarily involved in the regulation of various physiological processes, including the menstrual cycle and pregnancy. It is produced in the adrenal glands and gonads and is a key intermediate in the synthesis of cortisol and other corticosteroids. In clinical settings, 21-hydroxyprogesterone is often measured to assess adrenal function and diagnose conditions such as congenital adrenal hyperplasia. The substance is typically found in a solid state at room temperature and is soluble in organic solvents. Its stability and reactivity can be influenced by environmental factors such as pH and temperature, making it important to handle it under controlled conditions in laboratory settings.

5-A-pregnane-3-B-21-diol-20-one

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3-β,5-alfa-Tetrahydrodeoxycorticosterone

3²,21-Dihydroxy-5±-pregnan-20-one-d4

Applications 3β,5α-Tetrahydrodeoxycorticosterone is a novel derivative of the steroid Dehydroepiandrosterone (DHEA), a known uncompetitive inhibitor of Glucose 6-Phosphate Dehydrogenase (G6PD). Studies have shown that 3β,5α-Tetrahydrodeoxycorticosterone may have potential function in the modulation of calcium and GABAA-gated chloride channel currents found in rat and guinea-pig neurons.
References Hamilton, N.M., et al.: J. Medn. Chem., 55, 4431 (2012); Ffench, M., et al.: Steriods., 64, 76 (1999);


CAS 567-01-1: 5-A-pregnane-3-B-21-diol-20-one

3-β,5-alfa-Tetrahydrodeoxycorticosterone

Ref: 4Z-C-1048

3²,21-Dihydroxy-5±-pregnan-20-one-d4

Ref: 3D-AAA56701

3β,5α-Tetrahydrodeoxycorticosterone

Ref: TR-T293290