CAS 573-40-0: Rapanone

Rapanone (2,5-Dihydroxy-3-tridecyl-[1,4]benzoquinone) is a natural benzoquinone that is a potent and selective inhibitor of human synovial PLA2.

Rapanone is a bioactive compound classified as a quinone, which is isolated from the Annona species, particularly from the plant family Annonaceae. This compound is known for its interaction with cellular respiration mechanisms, where it specifically acts as an inhibitor of mitochondrial NADH-ubiquinone oxidoreductase, also known as complex I of the electron transport chain. The inhibition of complex I interferes with ATP production by disrupting the proton gradient required for ATP synthesis, leading to a depletion of energy within the cell. Rapanone’s mode of action makes it a significant object of study for scientists looking into its potential applications in pharmacology and toxicology. Its ability to modulate mitochondrial function has implications for the development of treatments targeting cancer cells, as well as for understanding toxicity mechanisms in various biological systems. Research on Rapanone contributes to a broader understanding of how natural products from the Annonaceae family can influence bioenergetic processes and offers a pathway for developing novel therapeutic agents.

Rapanone