CAS 5845-67-0: Cyclo(glycyl-L-leucyl)

Morphine tolerance peptide is a cyclic peptide analog of morphine. It has been shown to have an affinity for the kappa-opioid receptor that is similar to that of morphine, but it has a higher potency and a longer duration of action. The molecular modeling study indicates that the analog interacts with the receptor in a similar manner as morphine and exhibits high selectivity for this receptor. The analog also shares many of the same features as morphine in terms of depressant effect and locomotor activity, but does not produce any kind of withdrawal syndrome. The Morphine Tolerance Peptide is a cyclic peptide analog of morphine. This drug binds to the kappa-opioid receptors with high affinity, which are responsible for pain relief and feelings of euphoria when opioids bind to them. It has been shown to be more potent than morphine and last longer than morphine, meaning it can be taken less frequently for prolonged pain relief without experiencing withdrawal symptoms.

Formally derived from the C-terminal dipeptide of oxytocin., cyclo(Leu-Gly) is active in memory processes. The diketopiperazine blocks the narcotic-induced dopamine receptor supersensitivity.

Cyclo(Gly-L-Leu) is a cyclic peptide that binds to the kappa opioid receptors, which are involved in the regulation of motility. Cyclo(Gly-L-Leu) has been shown to stimulate locomotor activity and inhibit pain transmission in the rat striatum. It also inhibits dopamine release from presynaptic terminals following chronic exposure. The molecular modeling study of this compound shows that it is highly stable because of its intermolecular hydrogen bonding interactions.

Applications Cyclo(Leu-Gly) is an antimicrobial compound produced by Latobacillus plantarum. References Niku-Paavola, M., et al.: J. Appl. Microbiol., 86, 29 (1999)