CAS 588-07-8: N-(3-Chlorophenyl)acetamide

3'-Chloroacetanilide is a chemical compound that has been shown to inhibit the acetylation of adenosine nucleotides in vitro, leading to an increase in ATP levels. 3'-Chloroacetanilide also inhibits the deamination of guanosine nucleotides and blocks the synthesis of purines. The molecular modeling studies of this chemical have shown that it could be a potential inhibitor for cancer cells. In vivo experiments have shown that 3'-chloroacetanilide can cause a decrease in tumor size and weight as well as an increase in apoptosis. When incubated with rat hepatocytes, 3'-chloroacetanilide caused a significant drop in ATP levels and an increase in AMP levels. This study also showed that 3'-chloroacetanilide is metabolized into its glucuronide conjugate, which is excreted by the kidneys.br>br> br> 3'-Chlor

Applications 3-Chloroacetanilide is a major metabolite of chlorpropham. An acetanilide herbicide derivative. References Carrera, G., et al.: Arch. Environ. Cont. Tox., 35, 89 (1998); Freitas, M. R., et al.: Bull. Environ. Contam. Toxicol., 92, 143 (2014)