CAS 59-06-3: Ethopabate

Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereof

Ethopabate (Ethyl pabate) is an inhibitor of folate metabolism, used as a coccidiostat in poultry.

Ethopabate is a salt of ethopropazine and sodium carbonate. It is used in pharmaceutical preparations as an antiparasitic agent. The chemical composition of the salt is CHNO, with one hydrogen bond between the ethopropazine and sodium carbonate. Ethopabate has been shown to be active against amprolium-resistant coccidia in human serum, as well as being an analytical reagent for detecting monoclonal antibodies. This chemical can be used to prepare a polymeric matrix for use in fluorescence detection or for antimicrobial agents. Hydrochloric acid and UV light are used to synthesize this compound.

Ethopabate

Ethopabate

Ethopabate

Applications A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens. References Zeng, M. et al.: Zhongguo Shouyi Jishengchongbing, 15, 18 (2007); Rogers et al.: Proc. Soc. Exp. Biol. Med., 117, 488 (1964); Buhs et al.: J Parmacol. Exp. Ther., 154, 357 (1966);

Applications A supplementary drug that improves the coccidiostatic effect of nicarbazin and amprolium in order to cure coccidiosis in chickens. References Zeng, M. et al.: Zhongguo Shouyi Jishengchongbing, 15, 18 (2007); Rogers et al.: Proc. Soc. Exp. Biol. Med., 117, 488 (1964); Buhs et al.: J Parmacol. Exp. Ther., 154, 357 (1966);