1,3-Diethyl 2-nitropropanedioate, with the CAS number 603-67-8, is an organic compound characterized by its diester functional groups and a nitro substituent. It features a propanedioate backbone, which is a dicarboxylic acid derivative, where two ethyl groups are attached to the first and third carbon atoms, and a nitro group is positioned at the second carbon. This compound is typically a yellowish liquid or solid, depending on its purity and temperature. It is known for its reactivity, particularly in organic synthesis, where it can participate in various chemical reactions such as nucleophilic substitutions and condensation reactions. The presence of the nitro group enhances its electrophilic character, making it useful in the synthesis of more complex molecules. Additionally, 1,3-Diethyl 2-nitropropanedioate may exhibit moderate toxicity, necessitating careful handling and appropriate safety measures during its use in laboratory or industrial settings. Its applications can extend to pharmaceuticals, agrochemicals, and other fields requiring specialized organic compounds.

1,3-Diethyl 2-nitropropanedioate

603-67-8: 1,3-Diethyl 2-nitropropanedioate, Diethyl 2-nitromalonate, Diethyl Nitropropanedioate, Malonic acid, nitro-, diethyl ester, NSC 140874, Propanedioic acid, 2-nitro-, 1,3-diethyl ester, Propanedioic acid, nitro-, diethyl ester, Diethyl nitromalonate

Diethyl nitromalonate

Diethyl 2-nitromalonate

Diethyl nitromalonate is a synthetic drug that is used as an anti-inflammatory and immunosuppressant. It has been shown to be an effective treatment for autoimmune diseases, and it has also been used in cancer therapy. Diethyl nitromalonate inhibits the synthesis of inflammatory compounds such as prostaglandins and leukotrienes. The drug binds to the integrin receptor on the surface of white blood cells, interfering with the inflammatory response. Diethyl nitromalonate was first synthesized by reacting benzyl groups with hydrochloric acid and sodium hydroxide solution. This reaction creates a number of reactive intermediates, which are then reacted with fluorine to form diethyl nitromalonate. Diethyl nitromalonate also reacts with nitrogen atoms to form a benzene ring, which is then followed by a second reaction that produces malonic acid.

CAS 603-67-8: 1,3-Diethyl 2-nitropropanedioate

Diethyl nitromalonate

Ref: IN-DA003PH2

Diethyl 2-nitromalonate

Ref: 10-F242007

Diethyl nitromalonate

Ref: 3D-FD63436