CAS 6104-71-8: N-desmethylclozapine
Formula:C17H17ClN4
InChI:InChI=1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2
InChI key:InChIKey=JNNOSTQEZICQQP-UHFFFAOYSA-N
SMILES:ClC=1C=C2N=C(C=3C(NC2=CC1)=CC=CC3)N4CCNCC4
Synonyms:- 5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(1-piperazinyl)-
- 8-Chloro-11-(1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
- 8-chloro-11-(piperazin-1-yl)-10H-dibenzo[b,e][1,4]diazepine
- Acp 104
- Demethylclozapine
- Desmethylclozapine
- N-Demethylclozapine
- Norclozapine
- N-Desmethylclozapine
- N-Desmethylclozapine
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Found 15 products.
Ref: IN-DA00EB3S
Discontinued productN-Desmethylclozapine
CAS:Formula:C17H17ClN4Purity:≥ 97.0%Color and Shape:Yellow powderMolecular weight:312.808-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
CAS:Controlled ProductFormula:C17H17ClN4Color and Shape:NeatMolecular weight:312.80N-Desmethylclozapine
CAS:Formula:C17H17ClN4Purity:>95.0%(GC)Color and Shape:White to Yellow powder to crystalMolecular weight:312.80N-Desmethylclozapine
CAS:M01651 - N-DesmethylclozapineFormula:C17H17ClN4Purity:>99%Color and Shape:SolidMolecular weight:312.79998779296875Clozapine EP Impurity C HCl Salt
CAS:Formula:C17H17ClN4·HClColor and Shape:Yellow SolidMolecular weight:312.80 36.46N-Desmethyl Clozapine
CAS:Controlled ProductApplications N-Desmethyl Clozapine is a metabolite of Clozapine (C587500). N-Desmethyl Clozapine is a potent, allosteric agonist at human M1 receptors and is able to potentiate hippocampal NMDA receptor currents through M1 receptor activation. References Sur, C., et al.: Proc. Nat. Acad. Sci. U. S. A., 100, 13674 (2003); Kuoppamaki, M. et al.: Eur. J. Pharm. Mol. Pharm. Sect., 245, 179 (1993); Olessen, O.V., et al.: J. Chromatog., 622, 39 (1993); Pirmohamed, M., et al.: J. Pharmacol. Exp. Ther., 272, 984 (1995)Formula:C17H17ClN4Color and Shape:Light YellowMolecular weight:312.80N-Desmethyl clozapine
CAS:N-Desmethyl clozapine is a metabolite of the anti-psychotic drug clozapine. It has been shown to have similar effects to clozapine and can be used as an alternative treatment for chronic schizophrenia. The metabolite has been detected in human serum using a chromatographic method, which is an analytical technique that separates molecules based on their size and charge. N-Desmethyl clozapine was found to have a longer half-life than the parent compound, with a detection limit of 1 ng/mL in human serum. This metabolite also has been shown to inhibit fatty acid synthase activity and COX-1 activity in vitro, which may be responsible for its antipsychotic effects.Formula:C17H17ClN4Purity:Min. 95%Molecular weight:312.8 g/molN-Desmethylclozapine
CAS:N-Desmethylclozapine: 5-HT2C antagonist (IC50: 7.1 nM), dopamine D4 antagonist, δ-opioid agonist.Formula:C17H17ClN4Purity:97.25%Color and Shape:Yellow Crystalline SolidMolecular weight:312.8Ref: TM-T5158
2mg35.00€5mg50.00€10mg84.00€25mg160.00€50mg248.00€100mg364.00€200mg517.00€1mL*10mM (DMSO)62.00€
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