CAS 61145-33-3: Cyanomethyl 2,3,4,6-Tetra-O-Acetyl-1-Thio-b-D -Galactopyranoside

Cyanomethyl 2,3,4,6-tetra-O-acetyl-b-D-thioglucopyranoside is a synthetic glycosylation agent. It is an acetal derivative of b-D-thioglucopyranoside with a terminal methyl group at C2 and a fluorine atom at C6. This product can be used to modify saccharides and sugars in a variety of ways. It has been shown to react with various carbohydrates including polysaccharides and oligosaccharides. Synthetic glycosylations are often used in the synthesis of complex carbohydrates for use in pharmaceuticals or chemical engineering. The CAS number for this product is 61145-33-3.

Cyanomethyl 2,3,4,6-tetra-O-acetyl-1-thio-β-D-galactopyranoside

Applications The nitrile of the cyanomethyl group can be converted to a methyl imidate group by treatment with sodium methoxide or HCl which can be used to attach the sugar to a protein. References Lee, Y-C, et al.: Biochemistry, 15, 18, 3956 (1976), Lee, Y-C, et al.: Biochemistry, 19, 4899 (1980)

Cyanomethyl 2,3,4,6-tetra-O-acetyl-b-D-thiogalactopyranoside is an important reagent for the synthesis of glycosides and oligosaccharides. This substance has been used to synthesize a variety of modified saccharides, such as methylated sugars and fluorinated saccharides. It also has been applied to the synthesis of complex carbohydrates with the click modification.