CAS 61190-10-1: N-Benzylaminoacetaldehyde diethyl acetal

(Benzylamino)acetaldehyde diethyl acetal

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

N-Benzylaminoacetaldehyde diethylacetal is a synthetic compound that has been used as a model for the neurokinin substance P. It can be used to study the mechanisms of action of this substance and its role in the body. The N-benzyl aminoacetaldehyde diethyl acetal has antimalarial activity, but only against plasmodium falciparum and trypanosoma brucei. This model compound has also been shown to have diagnostic properties by increasing chloride efflux, which can be measured using an ion selective electrode. The synthesis of N-benzylaminoacetaldehyde diethyl acetal begins with the reaction between ammonium and chloroacetic acid to form a chloroamide, which is then reacted with benzylamine. This compound is structurally similar to substance P, but lacks many of its biological activities due to its lack of tachykinin activity.