CAS 6131-99-3: Sodium cacodylate trihydrate

Sodium cacodylate trihydrate, 98%

Sodium cacodylate,is used as an arsinate compound for proteomics research. It is used as a buffer in electron microscopy. This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.

Sodium cacodylate trihydrate is a buffering agent that can be used in biochemical research. It is prepared by the reaction of acetic acid with sodium bicarbonate and calcium oxide. Sodium cacodylate trihydrate interacts with various ions to maintain pH and has a redox potential of -0.6 volts. The buffer solution exhibits pH stability for at least 24 hours when stored at 4 degrees Celsius. This buffer can be used in vitro and in vivo experiments, including measurements of human serum, plasma mass spectrometry, polymerase chain reactions, and cellular physiology studies. Sodium cacodylate trihydrate also binds to epidermal growth factor (EGF) and hydroxyl groups on proteins, which may explain why it has been shown to have water vapor absorption properties.

Cacodylic acid sodium salt is frequently used as a buffering agent during the preparation and fixation of biological samples for transmission in electron microscopy. It is also used as a buffer for formulating screens and for optimization. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Cacodylic acid, employed extensively in buffers for electron microscopy techniques and in introducing arsenic into proteins for single-wavelength anomalous diffraction (SAD) phasing in protein crystallography, has been found to elevate tumor formation risk in the bladder, kidney, liver, and thyroid gland of rats exposed to carcinogens, at concentrations starting from as low as 50 ppm for the bladder.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.