CAS 61613-20-5: Benzenesulfonamide, N-(2-iodophenyl)-4-methyl-

N-Tosyl-2-iodoaniline is a synthetic compound that exhibits selective toxicity in humans and rats. It has been shown to be an active natural product against muscle, but not against the liver, spleen, kidney, or brain. N-Tosyl-2-iodoaniline cross-couples with amines to produce ethyl esters by a palladium-catalyzed reaction. This synthesis can be applied in the synthesis of biologically active compounds.

Applications N-Tosyl-2-iodoaniline is used in the synthetic preparations of spiro-heterocycles as potential inhibitors of SIRT1. References Rambabu, D., et al.: Bioorg. Med. Chem. Lett., 23, 1351 (2013); Rixson, J.E., et al.: Europ. J. Org. Chem., 2012, 544 (2012);