CAS 619-67-0: p-Hydrazinobenzoic acid

Deferasirox impurity F CRS

4-Hydrazinobenzoic acid

Aromatic organic derivatives of hydrazine or of hydroxylamine

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications 4-Hydrazinobenzoic Acid, is an organic building block used for the synthesis of various chemical and pharmaceutical compounds. It can be used for the synthesis of Deferasirox (D228650), an orally active tridentate iron chelator. References Ying, Ch., et al.: Xiandai Yaowu Yu Linchuang, 27, 446 (2012); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003), Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003);

4-Hydrazinobenzoic acid is a chemical compound that is used as an inhibitor of DNA synthesis. It prevents the formation of hydrogen bonds between nucleotides in DNA, which prevents the synthesis of new DNA strands. 4-Hydrazinobenzoic acid has been shown to inhibit the growth of human breast cancer cells by reactivating the tumor suppressor genes p21 and Rb1, which are responsible for regulating cell cycle progression. This compound also inhibits the production of hydrogen chloride (HCl) in reaction solutions containing sodium hypochlorite (NaOCl).