CAS 622-26-4: 4-Piperidineethanol

4-(2-Hydroxyethyl)piperidine

4-Piperidineethanol is a chemical compound that is used in the synthesis of DNA. It is also used as a solvent for other organic compounds and is a component of certain pesticides. 4-Piperidineethanol has been shown to enhance the cytotoxicity of anticancer drugs such as cisplatin and etoposide, while reducing their toxicity. It can be added to solutions at temperatures up to 56°C without decomposition or formation of byproducts. 4-Piperidineethanol binds to DNA and intercalates between the base pairs, which increases its solubility in water and enhances the binding affinity with DNA.

Applications 4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK References Tomita, N., et al.: Bioorg. Med. Chem., 23, 1779 (2013); Negoro, K., et al.: Bioorg. Med. Chem., 20, 6442 (2012); Giang, H.N., et al.: Macromole. Chem. Phy., 213, 982 (2012);

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.