CAS 624-49-7: Dimethyl fumarate

Acyclic polycarboxylic acids and their anhydrides, halides, peroxides and their derivatives, nesoi

Dimethyl fumarate (DMF) is a drug that acts as a prodrug for the active metabolite monomethyl fumarate (MMF). It is used in the treatment of psoriasis and other skin diseases, including erythema nodosum leprosum. DMF has been shown to significantly up-regulate the expression of proliferating cell nuclear antigen (PCNA), which is a response element for pdgf-bb. DMF also has antioxidant properties, which may be due to its ability to inhibit reactive oxygen species production. This drug also inhibits the activity of certain enzymes and blocks drug transporters that are involved in bowel disease.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Dimethyl fumarate acts as an immunomodulator. It is also used in cycloaddition reactions involving ylides, benzenes and amino acids. It is added to food grains,tobacco,leather and preservation. Clothing This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Dimethyl fumarate is the methyl ester form of Fumaric Acid (F500380), and is a compound used as a treatment for the relapsing forms of multiple sclerosis and psoriasis. Dimethyl fumarate is effective in treating multiple sclerosis by mediating the activation of the nuclear 1 factor (Nrf2) antioxidant response pathway, resulting in neuroprotective effects. Dimethyl fumarate is also used in cycloaddition reactions involving ylides, benzenes and amino acids. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Albrecht, P., et al.: J. Neuroinflammation, 9, 2094 (2012); Chen, X. et al.: J. Am. Chem. Soc., 130, 5652 (2008); Gold, R., et al.: New Engl. J Med., 367, 1098 (2012); Gothelf, A. et al.: Angew. Chem., Int. Ed., 41, 4236 (2002); Schmidt, T., et al.: Bioorg. Med. Chem., 15, 333 (2007)

Dimethyl fumarate (DMF) is an orally Nrf2 activator. Dimethyl fumarate has antimicrobial and anti-inflammatory activities. Cost-effective and quality-assured.

Dimethyl fumarate

Dimethyl fumarate