CAS 62455-70-3: Cyclohexanepropanenitrile, b-oxo-

Applications β-oxo-Cyclohexanepropanenitrile is used in the preparation of pyrazoloquinazolinone derivatives as PARP-1 inhibitors. In addition, it is used in the preparation of benzoxazoyl amino cyanopyrimidines which act as negative allosteric mGlu5 modulators. Used in anxiety, depression and addiction treatment. References Orvieto, F. et al.: Bioorg. Med. Chem. Lett., 19, 4196 (2009); Mueller, R. et al.: ChemMedChem., 7, 406 (2012);

Curvularia lunata is a fungus that produces 3-cyclohexyl-3-oxopropanenitrile, an alkylating agent. Curvularia lunata has been shown to be effective in the treatment of inflammatory diseases and allergic diseases. The mechanism of action for its anti-inflammatory effects is not yet known, but it may be due to its ability to reduce the levels of prostaglandins and leukotrienes. Curvularia lunata also contains a chemical called optically active 3-cyclohexyl-3-oxopropanenitrile, which can be used as a starting material for the synthesis of other optically active compounds. Curvularia lunata is used as a natural product to synthesize stereoselective compounds with high optical purity.

3-Cyclohexyl-3-oxopropanenitrile