CAS 6265-73-2: N-(2-Hydroxyethyl)nicotinamide

Nicorandil amide

Nicorandil impurity standard

N-(2-Hydroxyethyl)nicotinamide is a nicotinamide derivative that has been used as an experimental drug for the treatment of heart disease. In vivo studies have shown that it can improve cardiac function and reduce systolic pressure. N-(2-Hydroxyethyl)nicotinamide is also a matrix metalloproteinase inhibitor, which prevents the breakdown of collagen in connective tissue. This chemical has been shown to have a protective effect against malonic acid-induced myocardial damage in rats. It also inhibits the population growth of bacteria and yeast, which may be due to its anti-inflammatory properties.

Applications N-(2-Hydroxyethyl)nitotinamide is an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal. References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)

Applications N-(2-Hydroxyethyl)nitotinamide-d4 is labelled N-(2-Hydroxyethyl)nitotinamide (H942365), an intermediate used to prepare oxadiazole oxide derivatives as vasodilators. It is also a derivative of Nicorandil (N398500) which is an antiaginal. References Boschi, D., et al.: Bioorg. Med. Chem., 8, 1727 (2000); Nagai, H., et al.: Chem. Pharm. Bull., 32, 1063 (1984); Ma, C., et al.: J. Pharm. Biomed. Anal., 47, 677 (2008)