CAS 6287-83-8: 1H-benzimidazole-6-carbonitrile

1H-Benzimidazole-5-carbonitrile

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1H-Benzimidazole-5-carbonitrile is a product that belongs to the group of aminopyridine derivatives and has potent activity in vitro. It can be orally administered and has been shown to have pharmacological properties. 1H-Benzimidazole-5-carbonitrile has been shown to inhibit the biosynthesis of prostaglandin E2 by blocking the conversion of arachidonic acid into PGH2 by inhibiting cyclooxygenase, which is an enzyme necessary for the synthesis of prostaglandins. This drug also inhibits platelet aggregation, which is caused by the release of thromboxane A2 from platelets. 1H-Benzimidazole-5-carbonitrile binds to imidazole rings in proteins and prevents them from forming hydrogen bonds with other amino acids, which disrupts protein folding. X-ray crystallographic studies have been used to optimize this drug for oral administration and