CAS 6293-09-0: 3a,7a-dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione

1H-Imidazo[4,5-d]pyridazine-4,7-diol is an unsaturated heterocyclic compound. It reacts with phosphorus oxychloride to form the phosphorus oxychloride adduct. The alkylating properties of this compound are due to the presence of an unsaturated C=C bond in the molecule. The binding of 1H-imidazo[4,5-d]pyridazine-4,7-diol to DNA is thought to be due to its ability to intercalate between base pairs and cause crosslinking of DNA strands. This causes a decrease in DNA synthesis and cell division. Additionally, 1H-imidazo[4,5-d]pyridazine-4,7-diol can react with hydrazine or halogen in a hypotensor fashion to form an alkylating agent that inhibits protein synthesis by interfering with ribonucleotide

1H-Imidazo[4,5-d]pyridazine-4,7-diol is a phosphorus oxychloride adduct that is used as an alkylating agent. It has been shown to react with unsaturated alkyl groups and also reacts with halogens to form halogenated products. 1H-Imidazo[4,5-d]pyridazine-4,7-diol can be used in the synthesis of hypotensors.