CAS 632-85-9: Wogonin

5,7-Dihydroxy-8-Methoxy-2-Phenyl-4H-Chromen-4-One

Oxygen-heterocyclic compound

Wogonin is one major constituent of Scutellaria baicalensis, possesses potent anticancer activities , the activities are largely due to their abilities to scavenge oxidative radicals, to attenuate NF-kappaB activity, to inhibit several genes important for regulation of the cell cycle, to suppress COX-2 gene expression and to prevent viral infections.

Wogonin

Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.

Applications Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia. References Takagi, R. et al.: Int. J. Inflamm., 571508, 9 (2014); Xu, X. et al.: Biochem. Pharm., 92, 220 (2014);

Wogonin analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Wogonin is a bioactive flavonoid compound, which is isolated from the roots of the plant Scutellaria baicalensis, commonly known as Baikal skullcap. Its mode of action involves modulating various signaling pathways, including the inhibition of pro-inflammatory cytokines and the suppression of cancer cell proliferation through the induction of apoptosis and cell cycle arrest. By influencing these molecular pathways, Wogonin exhibits significant pharmacological potential. In scientific research, Wogonin is primarily utilized for its anti-inflammatory and anticancer properties. It has been shown to exhibit neuroprotective effects, making it a candidate for the development of therapies for neurodegenerative diseases. Additionally, its antioxidant activity contributes to cellular protection against oxidative stress. The compound's ability to selectively target cancer cells while sparing normal cells has garnered interest in oncology research. Ongoing studies are exploring its efficacy and safety profiles, as well as its synergistic effects when used in combination with conventional therapeutic agents.