N-Acetyl-L-lysine-N-methylamide, also known by its CAS number 6367-10-8, is a derivative of the amino acid lysine. This compound features an acetyl group and a methylamide group attached to the lysine backbone, which influences its solubility and reactivity. It is typically a white to off-white crystalline solid, soluble in polar solvents such as water and methanol, due to the presence of both hydrophilic acetyl and amide functional groups. The compound is of interest in biochemical research, particularly in studies related to protein modification and epigenetics, as acetylation plays a crucial role in regulating gene expression. Its structure allows it to participate in various biochemical pathways, potentially acting as a substrate or inhibitor in enzymatic reactions. Additionally, N-Acetyl-L-lysine-N-methylamide may exhibit biological activities, including effects on cellular metabolism and signaling pathways. As with many amino acid derivatives, it is important to handle this compound with care, following appropriate safety protocols in laboratory settings.

N-A-acetyl-L-lysine-N-methylamide*free base

6367-10-8: (2S)-2-(Acetylamino)-6-amino-N-methylhexanamide, (2S)-2-Acetamido-6-amino-N-methylhexanamide, Ac-Lys-NHMe, Hexanamide, 2-(acetylamino)-6-amino-N-methyl-, (2S)-, Hexanamide, 2-(acetylamino)-6-amino-N-methyl-, (S)-, Hexanamide, 2-acetamido-6-amino-N-methyl-, L-, N-Acetyl-L-lysine methylamide, N-Acetyl-N′-methyllysylamide, Nα-Acetyllysine methylamide, N~2~-acetyl-N-methyl-L-lysinamide, Nα-Acetyl-L-lysine-N-methylamide

Ac-Lys-NHMe

N-alpha-Acetyl-L-lysine methyl amide is a lysine analogue that forms electrostatic interactions with histidine. This interaction has been shown to affect the conformational stability of the peptide, which can be studied using NMR spectroscopy. The intramolecular hydrogen bonds between the two molecules are also affected by this interaction. N-alpha-Acetyl-L-lysine methyl amide is sensitive to changes in pH and ionic strength, and can undergo resonance when it interacts with other molecules or ions. These resonances can be simulated with molecular simulations or model compounds.

CAS 6367-10-8: N-A-acetyl-L-lysine-N-methylamide*free base

Ac-Lys-NHMe

Ref: 01-4000925

N-α-Acetyl-L-lysine methyl amide

Ref: 3D-FA48141

AC-LYS-NHME

Ref: IN-DA00E9ID

Na-Acetyl-L-lysine methyl amide

Ref: 10-F492760