CAS 638-02-8: 2,5-Dimethylthiophene

2,5-Dimethylthiophene is used as an intermediate in organic synthesis. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2,5-Dimethylthiophene

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2,5-Dimethylthiophene is a metastable form of 2,5-dimethylthiophenesulfonic acid (DTPS) that can be prepared by hydrolysis or chlorination of 2,5-dimethylthiophene. DTPS is used as an analytical reagent in the detection of fatty acids and chloride ions with high sensitivity. The activation energies for the reaction between DTPS and chloride ions are 25-30 kcal/mol. The reaction mechanism for this process includes nucleophilic attack on the sulfur atom followed by a rearrangement to form a sulfonyl chloride. Reaction products include amines and thiosulfate.