CAS 64490-92-2: 1H-Pyrrole-2-acetic acid, 1-methyl-5-(4-methylbenzoyl)-, sodium salt, hydrate (1:1:2)

Analgesics, antipyretics and non-hormonal anti-inflammatory agents

Tolmetin sodium dihydrate is an NSAID that inhibits COX-1 and COX-2 with IC50s of 0.35μM and 0.82μM.

Tolmetin sodium salt dihydrate is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the family of drugs known as pyrazolones. It has been shown to have tumoricidal activity against human colon cancer cells and is used in the treatment of inflammation, pain, and arthritis. Tolmetin sodium salt dihydrate is available in capsule form as well as a powder for oral administration. Tolmetin sodium salt dihydrate demonstrates chemical stability and does not degrade when exposed to chlorine gas. The drug also has anti-inflammatory properties that are mediated by inhibition of prostaglandin synthesis at the cellular level.

Tolmetin Sodium is an anti-inflammatory, antirheumatic agent. It can inhibit aldo-keto reductases (e.g., IC50 = 2.39 μM for human aldose reductase), a family of enzymes that catalyze the NADPH-dependent reduction of carbonyl groups in a number of important steroid, metabolic, and prostanoid molecules. It is a beta-adrenergic blocker. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Anti-inflammatory. References Carson, et al.: J. Med. Chem., 14, 646 (1971), Wong, S., et al.: J. Pharmacol. Exp. Ther., 185, 127 (1973), Brogden, R.N., et al.: Drugs, 15, 429 (1978),