CAS: 64907-21-7

7β,25-Dihydroxycholesterol is a steroid precursor that is synthesized in the liver and is converted to other steroid hormones. It has been shown to be important in immune function and as a regulator of cholesterol metabolism. In addition, 7β,25-Dihydroxycholesterol can bind to follicle cells and immune cells, activating signalling pathways. This compound has been shown to have an immunosuppressive effect on the humoral immune response by blocking antibody production. The receptor for 7β,25-Dihydroxycholesterol has been identified as GPER1. Knockout mice studies have shown that this receptor plays a role in regulating the number of plasma cells and oxysterols.

7β,25-Dihydroxycholesterol, an endogenous metabolite, functions as chemoattractants for immune cells that express EBI2 [1].