CAS 654671-78-0: Sitagliptin phosphate
Formula:C16H15F6N5O·H3O4P
InChI:InChI=1S/C16H15F6N5O.H3O4P/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22;1-5(2,3)4/h4,6,9H,1-3,5,7,23H2;(H3,1,2,3,4)/t9-;/m1./s1
InChI key:InChIKey=IQFYVLUXQXSJJN-SBSPUUFOSA-N
SMILES:C(F)(F)(F)C=1N2C(CN(C(C[C@@H](CC3=C(F)C=C(F)C(F)=C3)N)=O)CC2)=NN1.P(=O)(O)(O)O
Synonyms:- (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate
- 1,2,4-Triazolo[4,3-a]pyrazine, 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-, phosphate (1:1)
- 1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate (1:1)
- 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine phosphate
- Glactiv
- Januvia
- Mk 0431
- Mk 431
- Sitagliptin Phosphate Intermediates
- Sitagliptin phosphate
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Found 9 products.
Sitagliptin Phosphate
CAS:Controlled ProductApplications Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. References Kim, D., et al.: J. Med. Chem. 48, 141 (2005), Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005), Bergman, A., et al: Clin. Ther. 28, 55 (2006)Formula:C16H15F6N5O·H3O4PColor and Shape:NeatMolecular weight:505.31(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4 ,3-α]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate anhydrous
CAS:(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4 ,3-α]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one phosphate anhydrous (TZP) is a drug candidate for the treatment of diabetes. TZP is a prodrug that is metabolized by the liver and gut to the active compound sitagliptin phosphate (SGP). TZP has been shown to reduce plasma glucose levels in diabetic rats. In vitro experiments have shown that TZP inhibits dipeptidyl peptidase IV (DPP-IV), which is an enzyme that degrades incretins such as glucagon like peptide 1 and glucose dependent insulinotropic polypeptide. These findings suggest that TZFormula:C16H15F6N5O•H3O4PPurity:Min. 98 Area-%Color and Shape:PowderMolecular weight:505.31 g/molSitagliptin Phosphate
CAS:Formula:C16H15F6N5O·H3O4PColor and Shape:White To Off-White SolidMolecular weight:407.32 97.99Sitagliptin phosphate
CAS:Sitagliptin phosphate (MK-0431 phosphate) is a dipeptidyl peptidase-4 (DPP4) inhibitor.Formula:C16H18F6N5O5PPurity:99.72% - 99.72%Color and Shape:White SolidMolecular weight:505.31Sitagliptin Phosphate
CAS:Formula:C16H15F6N5O·H3PO4Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:505.311-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)-, phosphate (1:1)
CAS:Formula:C16H18F6N5O5PPurity:98%Color and Shape:SolidMolecular weight:505.30880019999995
![(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4 ,3-α]pyrazin-7(8H)-yl)-4-(2,4,5-t…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F3D%2Fthumb%2FFA10819.jpg&w=3840&q=75)
![1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA003U9W.jpg&w=3840&q=75)
