CAS 6602-32-0: 2-Bromo-3-pyridinol

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Bromo-3-hydroxypyridine

2-Bromo-3-hydroxypyridine

2-Bromo-3-hydroxypyridine is used to produce 2-bromo-4,6-diiodo-3-pyridinol. It is also used in azo dyes and in the synthesis of pterocellin A by reacting with kojic acid and in synthesis of orelline. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Bromo-3-pyridinol is a nicotinic acetylcholine receptor antagonist that has anti-influenza activity. It was synthesized as an analogue of the natural product pyridostigmine, which inhibited influenza in mice. 2-Bromo-3-pyridinol binds to the nicotinic acetylcholine receptor at the same site as nicotine and prevents it from being activated by acetylcholine. This drug also inhibits tumor growth and proliferation in vitro and in vivo, showing potent cytotoxicity against carcinoma cells by inhibiting protein synthesis and cell division. 2-Bromo-3-pyridinol has been shown to inhibit Alzheimer's disease in a mouse model of this disorder. The drug inhibits amyloid plaque formation and toxicity in cultured cells, suggesting its potential for treating this disease.